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- Title
Lymphocyte population in patients with tularemia.
- Authors
Pérez-Castrillón JL; Martín-Luquero M; Bachiller P; Mena J; Recio I; Jimenez A; Romero M; Herreros V
- Abstract
Background: The objective of study was to evaluate the evolution of lymphocyte population in patients with tularemia before initiating treatment and 1 year later and to evaluate their prognostic value.Patients and Methods: The patients were diagnosed of tularemia by compatible clinical manifestations and by an elevated titer of antibodies against Francisella tularensis (>1/160), seroconversion or isolation of F. tularensis in a clinical sample. The control group consisted of asymptomatic patients with chronic ischemic heart disease with negative serology against F. tularensis and Chlamydia pneumoniae. The patients were treated with streptomycin or ciprofloxacin. The following cell populations were determined by FACSCAN cytometer: T lymphocytes, helper T lymphocytes, suppressor T lymphocytes, activated T lymphocytes, T lymphocytes with NK activity, B lymphocytes, and NK cells. The progression was evaluated using clinical criteria.Results: During the initial determination, the patients presented statistically significant elevated values of total lymphocytes, T lymphocytes, activated T lymphocytes, and T lymphocytes with NK activity. The values had become normal 1 year after termination of treatment. There were no differences between those patients with a poor response to treatment and those with a positive one.Conclusions: Patients with tularemia initially presented a high total lymphocyte count, T lymphocytes, activated lymphocytes, and T lymphocytes with natural killer activity. The cell populations lack value as a prognostic marker.
- Publication
Journal of Applied Research, 2003, Vol 3, Issue 3, p282
- ISSN
1537-064X
- Publication type
Journal Article