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- Title
An unusual recurrent high-grade glioneuronal tumor with MAP2K1 mutation and CDKN2A/B homozygous deletion.
- Authors
Cheaney II, Barry; Bowden, Stephen; Krause, Katie; Sloan, Emily A.; Perry, Arie; Solomon, David A.; Han, Seunggu Jude; Wood, Matthew D.
- Abstract
Highlights from the article: ATRX expression was retained in tumor nuclei in both components, p53 staining was positive in only scattered tumor nuclei, and an IDH1-R132H stain was negative for mutant protein expression. The shared alterations of I MAP2K1 i mutation and I CDKN2A/B i homozygous deletion supports that low and high grade elements in this tumor represent morphologically distinct components of a single clonal neoplasm. Shared histopathologic features between this case and MVNT include foci of nodular growth and tumor cells with vacuolar alteration and a compatible immunophenotype. We cannot determine for certain whether the original tumor was a ganglioglioma, MVNT, mixed ganglioglioma/MVNT, or even another type of low-grade neuroepithelial neoplasm.
- Subjects
CENTRAL nervous system tumors
- Publication
Acta Neuropathologica Communications, 2019, Vol 7, Issue 1, pN.PAG
- ISSN
2051-5960
- Publication type
Letter
- DOI
10.1186/s40478-019-0763-x