We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Defect in efferocytosis leads to alternative activation of macrophages in Francisella infections.
- Authors
Mares, Chris A.; Sharma, Jyotika; Qun Li; Rangel, Edward L.; Morris, Elizabeth G.; Enriquez, Melissa I.; Teale, Judy M.
- Abstract
The macrophage is a versatile cell type that can sense and respond to a particular need based on the conditions of the microenvironment. Some studies have recently suggested that pathogens can directly influence the polarization of macrophages. As Francisella infections are characterized by intense necrotic infiltrates in the lung as well as in distal sites of infection, we sought to investigate whether pulmonary Francisella infections could cause the polarization of alternatively activated macrophages (M2/aaMs). Our results indicate that Francisella infections can cause the polarization of M2/aaM in vivo and that macrophages can be polarized toward an M2/aaM phenotype more potently if dead cell debris is used for stimulation in the presence and absence of Francisella infections. Finally, we also demonstrate that efferocytosis is inhibited in macrophages infected with Francisella, thus providing a potential explanation for the lack of clearance and eventual accumulation of dead cell debris associated with this disease.
- Subjects
MACROPHAGES; PATHOGENIC microorganisms; FRANCISELLA; INFECTION; GENOTYPE-environment interaction
- Publication
Immunology & Cell Biology, 2011, Vol 89, Issue 2, p167
- ISSN
0818-9641
- Publication type
Article
- DOI
10.1038/icb.2010.81