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- Title
blood flow, acidity and atrophic changes of the gastric mucosa in Mongolian gerbils infected with Helicobacter pylori.
- Authors
Miyazaki, Sebastião Mitsuji; Matsuda, Mimian Graciela; Misumi, Atsunobu; Honmyo, Ubehiko; Murakami, Akitoshi; Murata, Hiroshi; Sagara, Katsuro; Kurano, Ryouichi; Okabe, Hiroaki
- Abstract
Background: We used a Mongolian gerbil model to evaluate the effects of long-term Helicobacter pylori infection on blood flow, gastric acidity and atrophic change of the gastric mucosa. Methods: Infected animals were divided into eight groups according to the duration of infection: 3 months infection (MI), 6 MI, 9 MI, 12 MI, 18 MI, 24 MI, 30 MI and 36 MI ( n = 6 in the 3-30 MI groups and n = 11 in the 36 MI group). Control animals were divided into the same eight groups (3-36 MC; n = 6 in each group). Blood flow and gastric acidity were measured and atrophic changes were analyzed in each group. The gastric mucosa was divided into areas termed F (chief cells observed continuously), f1 (number of chief cells decreased and no longer continuous), f2 (parietal cells scattered and chief cells not seen) and P (only pyloric glands observed). Atrophic changes were classified as normal, mild, moderate and severe on the basis of the percentage of the F area and the presence or absence of the f2 area. Results: Blood flow did not show any significant difference between the control groups, but decreased significantly in the 12-36 MI groups compared with the 3-9 MI groups ( P < 0.0001). The pH was significantly higher in the 12-36 MC groups than in the 6 and 9 MC groups ( P < 0.002). The pH was significantly higher in the 9-36 MI groups than in the 6 MI group ( P < 0.006). Atrophic changes were not found in the 3-9 MC groups, but mild atrophic changes were observed in the 12-24 MC groups and moderate atrophic changes were observed in the 30 and 36 MC groups. Atrophic changes were moderate in the 3-18 MI groups and severe in the 24-36 MI groups. Conclusion: The present study shows that atrophic changes progress with aging naturally and that H. pylori infection accelerates this change to induce a severe decrease in blood flow and gastric acid secretion.
- Subjects
MONGOLIA; GERBILS; HELICOBACTER pylori infections; BLOOD flow; ACIDITY; MUCOUS membranes; DISEASES
- Publication
Digestive Endoscopy, 2001, Vol 10, Issue 4, p195
- ISSN
0915-5635
- Publication type
Article
- DOI
10.1046/j.1443-1661.2001.d01-8.x