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- Title
Proteomics reveals disturbances in the immune response and energy metabolism of monocytes from patients with septic shock.
- Authors
de Azambuja Rodrigues, Pedro Mendes; Valente, Richard Hemmi; Brunoro, Giselle Villa Flor; Nakaya, Helder Takashi Imoto; Araújo-Pereira, Mariana; Bozza, Patricia Torres; Bozza, Fernando Augusto; Trugilho, Monique Ramos de Oliveira
- Abstract
Sepsis results from a dyshomeostatic response to infection, which may lead to hyper or hypoimmune states. Monocytes are central regulators of the inflammatory response, but our understanding of their role in the genesis and resolution of sepsis is still limited. Here, we report a comprehensive exploration of monocyte molecular responses in a cohort of patients with septic shock via proteomic profiling. The acute stage of septic shock was associated with an impaired inflammatory phenotype, indicated by the down-regulation of MHC class II molecules and proinflammatory cytokine pathways. Simultaneously, there was an up-regulation of glycolysis enzymes and a decrease in proteins related to the citric acid cycle and oxidative phosphorylation. On the other hand, the restoration of immunocompetence was the hallmark of recovering patients, in which an upregulation of interferon signaling pathways was a notable feature. Our results provide insights into the immunopathology of sepsis and propose that, pending future studies, immunometabolism pathway components could serve as therapeutic targets in septic patients.
- Subjects
PROTEOMICS; IMMUNE response; ENERGY metabolism; SEPTIC shock; MONOCYTES
- Publication
Scientific Reports, 2021, Vol 11, Issue 1, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-021-94474-0