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- Title
APRIL-producing eosinophils are involved in gastric MALT lymphomagenesis induced by Helicobacter sp infection.
- Authors
Blosse, Alice; Peru, Sara; Levy, Michael; Marteyn, Benoit; Floch, Pauline; Sifré, Elodie; Giese, Alban; Prochazkova-Carlotti, Martine; Azzi Martin, Lamia; Dubus, Pierre; Mégraud, Francis; Ruskone Fournestraux, Agnès; Fabiani, Bettina; Copie Bergman, Christiane; Robe, Cyrielle; Hahne, Michael; Huard, Bertrand; Lehours, Philippe
- Abstract
The roles of the inflammatory response and production of a proliferation-inducing ligand (APRIL) cytokine in gastric mucosa-associated lymphoid tissue (MALT) lymphomagenesis induced by Helicobacter species infection are not clearly understood. We characterized the gastric mucosal inflammatory response associated with gastric MALT lymphoma (GML) and identified APRIL-producing cells in two model systems: an APRIL transgenic mouse model of GML induced by Helicobacter infection (Tg-hAPRIL) and human gastric biopsy samples from Helicobacter pylori-infected GML patients. In the mouse model, polarization of T helper 1 (tbet), T helper 2 (gata3), and regulatory T cell (foxp3) responses was evaluated by quantitative PCR. In humans, a significant increase in april gene expression was observed in GML compared to gastritis. APRIL-producing cells were eosinophilic polynuclear cells located within lymphoid infiltrates, and tumoral B lymphocytes were targeted by APRIL. Together, the results of this study demonstrate that the Treg-balanced inflammatory environment is important for gastric lymphomagenesis induced by Helicobacter species, and suggest the pro-tumorigenic potential of APRIL-producing eosinophils.
- Subjects
CYTOKINES; MUCOSA-associated lymphoid tissue lymphoma; HELICOBACTER diseases; EOSINOPHILS; GASTRITIS; LABORATORY mice
- Publication
Scientific Reports, 2020, Vol 10, Issue 1, pN.PAG
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-020-71792-3