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- Title
Restorative Effects of Inulin From Codonopsis pilosula on Intestinal Mucosal Immunity, Anti-Inflammatory Activity and Gut Microbiota of Immunosuppressed Mice.
- Authors
Zou, Yuan-Feng; Li, Cen-Yu; Fu, Yu-Ping; Feng, Xin; Peng, Xi; Feng, Bin; Li, Li-Xia; Jia, Ren-Yong; Huang, Chao; Song, Xu; Lv, Cheng; Ye, Gang; Zhao, Ling; Li, Yang-Ping; Zhao, Xing-Hong; Yin, Li-Zi; Yin, Zhong-Qiong
- Abstract
An inulin (CPPF), isolated from a traditional Chinese herbal medicine Codonopsis pilosula , was characterized and demonstrated with potential prebiotic activity in vitro before. Based on its non-digested feature, the intestinal mucosa and microbiota modulatory effects in vivo on immunosuppressed mice were investigated after oral administration of 200, 100 and 50 mg/kg of CPPF for 7 days. It was demonstrated that the secretions of sIgA and mucin 2 (Muc2) in ileum were improved by CPPF, and the anti-inflammatory activities in different intestine parts were revealed. The intestine before colon could be the target active position of CPPF. As a potential prebiotic substance, a gut microbiota restorative effect was also presented by mainly modulating the relative abundance of Eubacteriales , including Oscillibacter , unidentified Ruminococcus and Lachnospiraceae after high-throughput pyrosequencing of V4 region of 16S rRNA analysis. All these results indicated that this main bioactive ingredient inulin from C. pilosula was a medicinal prebiotic with enhancing mucosal immune, anti-inflammatory and microbiota modulatory activities.
- Subjects
INULIN; GUT microbiome; ANTI-inflammatory agents; SMALL intestine; CHINESE medicine; INTESTINES; INTESTINAL mucosa
- Publication
Frontiers in Pharmacology, 2022, Vol 13, p1
- ISSN
1663-9812
- Publication type
Article
- DOI
10.3389/fphar.2022.786141