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- Title
Bindung von Cortisol, Fluocortolon und Difluocortolon an Humanplasmaproteine.
- Authors
Fellier, H.; Gleispach, H.; Esterbauer, H.
- Abstract
The binding properties of [3H]cortisol, [3H]fluocortolone and [3H]difluocortolone by human plasma, human albumin, human-β- and γ-globulins have been studied by equilibrium dialysis. Cortisol, in physiological concentrations (0,4 /l), is 98% bound in human plasma at 25 ∘C, fluocortolone 96% and difluocortolone 85 %. Under physiological conditions cortisol is mainly bound to the corticosteroid binding globulin (transcortin). 2/3 of fluocortolone is bound to transcortin and 1/3 to albumin and globulins, whereas difluocortolone is mainly bound to albumin and to globulins but not to transcortin. The binding affinities of β- and γ-globulins are very low for the corticoids investigated, but they are higher for fluocortolone and difluocortolone than for cortisol. These results could be an explanation for the high biological activity of 9α-fluorocorticoids such as dexamethasone.
- Publication
Clinical Chemistry & Laboratory Medicine, 1977, Vol 15, Issue 10, p545
- ISSN
1434-6621
- Publication type
Article