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- Title
Identification of royal jelly as a potential new drug to protect the ovarian reserve and uterus against cyclophosphamide in rats.
- Authors
Bulbul, Mehmet; Tekce, Ali; Annac, Ebru; Korkmaz, Omer; Onderci, Muhittin; Korkmaz, Deniz; Demirci, Akin Mustafa
- Abstract
Objective: The aim of this study was to investigate the effect of royal jelly (RJ), a powerful natural antioxidant, on cyclophosphamide-induced ovarian damage. Methods: Thirty-two Wistar albino rats were divided into four groups. Oral treatment was administered to all rats for 16 days after a single intraperitoneal injection. The control group received intraperitoneal and oral saline; the RJ group received intraperitoneal saline and 100 mg/kg/day oral RJ; the cyclophosphamide group received intraperitoneal 100 mg/kg cyclophosphamide and oral saline; and the treatment group received intraperitoneal 100 mg/kg cyclophosphamide and 100 mg/kg/day oral RJ. The groups were compared in terms of ovarian reserve tests and histopathological changes in the ovary and uterus. Results: All follicle counts were higher in the treatment group than in the cyclophosphamide group. The increase in the number of preantral follicles (p=0.001) and the decrease in the number of atretic follicles (p=0.004) were statistically significant. RJ treatment significantly improved follicular degeneration and cortical fibrosis in the ovary and epithelial and gland degeneration in the uterus due to cyclophosphamide toxicity. Conclusion: According to these results, RJ reduces cyclophosphamide-related ovarian and endometrial damage in rats. For this reason, it should be further investigated to determine its effects on reproductive function.
- Subjects
OVARIAN reserve; ROYAL jelly; UTERUS; OVARIAN follicle; CYCLOPHOSPHAMIDE
- Publication
Clinical & Experimental Reproductive Medicine, 2023, Vol 50, Issue 1, p34
- ISSN
2233-8233
- Publication type
Article
- DOI
10.5653/cerm.2022.05596