We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Possible Involvement of Oxidative Stress in Salivary Gland of Patients with Sjögren's Syndrome.
- Authors
Ryo, Koufuchi; Yamada, Hiroyuki; Nakagawa, Yoichi; Tai, Yoshinori; Obara, Kumi; Inoue, Hiroko; Mishima, Kenji; Saito, Ichiro
- Abstract
Objective: To determine the involvement of oxidative stress in the salivary gland of patients with Sjögren's syndrome (SS). Methods: Oxidative damage to the gland was measured by 8-hydroxy-2′-deoxyguanosine (8-OHdG) and hexanoyl-lysine (HEL) using the SS saliva. In addition, lactate dehydrogenase (LDH) and mitochondrial glutamic-oxaloacetic transaminase (m-GOT), both general markers for cell damage, were also analyzed. Results: Increased levels of 8-OHdG and HEL were found in the saliva of SS patients, but not in that of patients with other salivary gland dysfunction or of healthy individuals. Levels of LDH and m-GOT were significantly correlated with 8-OHdG and HEL levels, respectively. Furthermore, the increased levels of 8-OHdG and HEL were also correlated in the SS saliva. Conclusion: These findings suggested the involvement of oxidative stress in glandular tissue destruction in SS. It was indicated that the detection of 8-OHdG and HEL in the saliva may become a useful tool for the diagnosis of SS. Copyright © 2006 S. Karger AG, Basel
- Publication
Pathobiology, 2006, Vol 73, Issue 5, p252
- ISSN
1015-2008
- Publication type
Article
- DOI
10.1159/000098211