We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Nrf2 Inhibits the Progression of Parkinson's Disease by Upregulating AABR07032261.5 to Repress Pyroptosis.
- Authors
Zhong, Yunxiao; Cai, Xiaodong; Ding, Li; Liao, Jinchi; Liu, Xu; Huang, Yiying; Chen, Xiaohong; Long, Ling
- Abstract
Pyroptosis is a critical cellular pathogenic mechanism associated with the development of multiple neurodegenerative disorders, including PD.[11],[23] We observed a significant increase in pyroptosis marker gene expression in the cellular and animal PD models, confirming the involvement of pyroptosis in PD pathogenesis. The pathological progression of PD is closely controlled by ROS biosynthesis and oxidative stress in the substantia nigra, and mediated by various cell death pathways including apoptosis, necroptosis, autophagic cell death, and pyroptosis.[6],[9],[11] However, the molecular mechanisms regulating pyroptosis during PD development are poorly understood.
- Subjects
MOVEMENT disorders; NEUROTROPHINS; PARKINSON'S disease; NLRP3 protein; PYROPTOSIS; NUCLEAR factor E2 related factor; LIFE sciences; DARDARIN
- Publication
Journal of Inflammation Research, 2022, Vol 15, p669
- ISSN
1178-7031
- Publication type
Article
- DOI
10.2147/JIR.S345895