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- Title
A novel method for methimazole determination using CdSe quantum dots as fluorescence probes.
- Authors
Fei Dong; Kewang Hu; Heyou Han; Jiangong Liang
- Abstract
A novel method has been developed for methimazole analysis based on the quenching of fluorescence emission from CdSe quantum dots by methimazole. Under optimum conditions, the calibration graph was linear over the range of 50 nM to 5 μM ( r2 = 0.990). The limit of detection (S/N = 3) was 30 nM. The R.S.D. for ten determinations of 500 nM methimazole was 3.4%. The method was applied to determine methimazole in tablets and rat urine, and the results were satisfactory, i.e. consistent with those of gas chromatography–mass spectrometry. The possible cause of fluorescence quenching is due to the exchange of surface capping organic molecules of quantum dots induced by methimazole.
- Subjects
FLUORESCENCE; RADIOACTIVITY; CHROMATOGRAPHIC analysis; SPECTROMETRY; SPECTRUM analysis
- Publication
Microchimica Acta, 2009, Vol 165, Issue 1/2, p195
- ISSN
0026-3672
- Publication type
Article
- DOI
10.1007/s00604-008-0120-4