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- Title
Interleukin 17A gene polymorphism rs2275913 is associated with osteitis after the Bacillus Calmette-Guérin vaccination.
- Authors
Liehu‐Martiskainen, Milla; Korppi, Matti; Teräsjärvi, Johanna; Vuononvirta, Juho; Huhtala, Heini; Nuolivirta, Kirsi; Kröger, Liisa; Peltola, Ville; Pöyhönen, Laura; He, Qiushui
- Abstract
<bold>Aim: </bold>Interleukin-17 (IL-17) appears to promote the host's defence against mycobacterial infections. This study evaluated the association between IL17A gene polymorphism and the risk of Bacillus Calmette-Guérin (BCG) osteitis after newborn vaccination and between IL17A gene polymorphism and IL-17A concentrations in serum.<bold>Methods: </bold>IL17A rs2275913 gene polymorphisms and serum IL-17A concentrations were studied in 132 adults aged 21-49 years from across Finland, who had BCG osteitis in infancy after a newborn BCG vaccination. The subjects were recruited in 2007-2008, and their whole-blood samples were sent to the National Institute for Health and Welfare, Turku, Finland. Their genotypes and minor allele frequencies were compared with 405 population-based unvaccinated controls aged two to three months from a prospective birth cohort study.<bold>Results: </bold>The genotypes and allele frequencies of IL17A rs2275913 differed significantly between the former BCG osteitis patients and controls. The genotype was variant in 75.8% of cases and 64.0% of controls (p = 0.012), and the minor allele frequency was 50.0% in the cases and 41.6% of the controls (p = 0.009). Serum IL-17 concentrations did not differ significantly between the cases with wild or variant genotypes.<bold>Conclusion: </bold>IL17A rs2275913 gene polymorphism was associated with a risk of BCG osteitis after vaccination.
- Subjects
OSTEITIS; INTERLEUKIN-17; GENETIC polymorphisms; BCG vaccines; TUBERCULOSIS vaccines; NEWBORN infant health; GENOTYPES; INTERLEUKINS; CASE-control method
- Publication
Acta Paediatrica, 2017, Vol 106, Issue 11, p1837
- ISSN
0803-5253
- Publication type
journal article
- DOI
10.1111/apa.14000