We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Astrovirus and digestive disorders in neonatal units.
- Authors
Chappé, Céline; Minjolle, Sophie; Dabadie, Alain; Morel, Laetitia; Colimon, Ronald; Pladys, Patrick
- Abstract
Aim: To describe clinical signs associated with Human Astrovirus (HAstV) in stools in neonatal units. Methods: During 2005-2006, all stool virology performed for isolated digestive symptoms or suspicion of neonatal infection was tested for HAstV by an amplified enzyme-linked immunoassay (IDEIA™ Astrovirus test, Dako Cytomation). Each newborn with a positive result (HAstV+ group) was retrospectively matched with the first following symptomatic newborn in the same care unit having a negative stool virology (HAstV− group). Clinical data were collected during two 3-day periods (just after faecal samples collection and 1 week before) and compared within and between each group. Results: Human astrovirus was detected in faeces of 68 newborns [gestational age: 31.4(28.8-34) weeks] at a post-natal age of 23 (15-42) days without seasonal dominance. Human astrovirus+ and HAstV− groups were comparable. Bloody stool (54.4% versus 14.7%, p < 0.01) and stage II-III necrotizing enterocolitis (20.6% versus 4.4%, p < 0.05) were more frequently observed in HAstV+ than in HAstV− group; these associations were confirmed by logistic regression analysis. Conclusion: This descriptive study argues for a possible association between HAstV and digestive symptoms in newborns specifically in preterm infants.
- Subjects
ASTROVIRUSES; NEONATAL infections; VIROLOGY; IMMUNOASSAY; NEONATAL necrotizing enterocolitis
- Publication
Acta Paediatrica, 2012, Vol 101, Issue 5, pe208
- ISSN
0803-5253
- Publication type
Article
- DOI
10.1111/j.1651-2227.2011.02569.x