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- Title
141 True Neuronal Heterotopia of the Middle Ear: A Case Report.
- Authors
AlZubaidi, Yasir; Abdulsattar, Jehan; Herrera, Guillermo; Al-Delfi, Firas
- Abstract
Heterotopias, also referred to as <italic>choristomas</italic> and <italic>ectopias</italic>, are characterized by the presence of normal-appearing tissue in an anatomic location in which they normally are not found. Heterotopias that occur in the middle ear usually include neuroglial tissue, most often representing acquired encephaloceles and rarely true neuronal heterotopias. Here we report a case of a 68-year-old woman who presented with left mastoid mass. Despite the patient past medical history of bilateral chronic seromucinous otitis media that was associated with conductive hearing loss, the imaging studies (MRI) of her brain revealed only a 0.3 cm left middle ear mass without any continuity with the central nervous system, thus excluding the clinical differential diagnosis of acquired encephalocele. Microscopic examination showed glial tissue with clusters of neurons. Immunohistochemical stains showed positive glial fibrillary acidic protein. Based on the radiological findings, microscopic examination and immunohistochemistry, a diagnosis of true neuronal heterotopia of the middle ear was rendered.
- Subjects
HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; COMPUTED tomography
- Publication
American Journal of Clinical Pathology, 2018, Vol 149, pS60
- ISSN
0002-9173
- Publication type
Article
- DOI
10.1093/ajcp/aqx119.140