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- Title
Low prevalence of H. pylori infection in HIV-positive patients in the northeast of Brazil.
- Authors
Fialho, Andréa Bc; Braga-Neto, Manuel B; Guerra, Eder Jc; Fialho, André Mn; Fernandes, Karine C; Sun, Juliana Lm; Takeda, Christianne Fv; Silva, Cícero Is; Queiroz, Dulciene Mm; Braga, Lucia Lbc; Fialho, Andréa B C; Guerra, Eder J C; Fialho, André M N; Sun, Juliana L M; Takeda, Christianne F V; Silva, Cícero I S; Queiroz, Dulciene M M; Braga, Lucia L B C
- Abstract
<bold>Background: </bold>This study conducted in Northeastern Brazil, evaluated the prevalence of H. pylori infection and the presence of gastritis in HIV-infected patients.<bold>Methods: </bold>There were included 113 HIV-positive and 141 age-matched HIV-negative patients, who underwent upper gastrointestinal endoscopy for dyspeptic symptoms. H. pylori status was evaluated by urease test and histology.<bold>Results: </bold>The prevalence of H. pylori infection was significantly lower (p < 0.001) in HIV-infected (37.2%) than in uninfected (75.2%) patients. There were no significant differences between H. pylori status and gender, age, HIV viral load, antiretroviral therapy and the use of antibiotics. A lower prevalence of H. pylori was observed among patients with T CD4 cell count below 200/mm3; however, it was not significant. Chronic active antral gastritis was observed in 87.6% of the HIV-infected patients and in 780.4% of the control group (p = 0.11). H. pylori infection was significantly associated with chronic active gastritis in the antrum in both groups, but it was not associated with corpus chronic active gastritis in the HIV-infected patients.<bold>Conclusion: </bold>We demonstrated that the prevalence of H. pylori was significantly lower in HIV-positive patients compared with HIV-negative ones. However, corpus gastritis was frequently observed in the HIV-positive patients, pointing to different mechanisms than H. pylori infection in the genesis of the lesion.
- Publication
BMC Gastroenterology, 2011, Vol 11, Issue 1, p13
- ISSN
1471-230X
- Publication type
journal article
- DOI
10.1186/1471-230X-11-13