We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Radiofrequency ablation triggers the migration of hepatocellular carcinoma cells by suppressing miR-148a-5p.
- Authors
Wang, Haicun; Cao, Yang; Hu, Kaiwen; Li, Quanwang; Yang, Yufei; Wang, Lanrong; Qin, Xiaoyan; Qiao, Bingli; Cheng, Liuqi; Li, Peipei; Dui, Weihua
- Abstract
Increasing evidences suggest that insufficient radiofrequency ablation (IRFA) can paradoxically promote tumor invasion and metastatic processes, whereas the effects of moderate hyperthermia on cancer progression are not well illustrated. Our study found that IRFA can increase the in vitro migration, invasion, and epithelial–mesenchymal transition (EMT) of hepatocellular carcinoma (HCC) cells via induction of Snail, a master regulator of EMT events. Among measured miRNAs, IRFA can decrease the expression of miR-148a-5p in HCC cells. Whereas overexpression of miR-148a-5p can reverse IRFA-induced migration of HCC cells and upregulation of Snail, mechanistically overexpression of miR-148a-5p can directly target and decrease the expression of protein kinase ATM (ataxia telangiectasia mutated), which can increase protein stability of Snail. Collectively, our data suggest that IRFA can regulate the miR-148a-5p/ATM/Snail axis to trigger migration of HCC cells.
- Subjects
CATHETER ablation; HEPATOCELLULAR carcinoma; EPITHELIAL-mesenchymal transition; ATAXIA telangiectasia; ATAXIA telangiectasia mutated protein; PROTEIN stability
- Publication
Biological Chemistry, 2020, Vol 401, Issue 8, p985
- ISSN
1431-6730
- Publication type
Article
- DOI
10.1515/hsz-2020-0130