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- Title
Urinary Excretion Kinetics of 9-(2-Diethylaminoethyl)-2-Phenylimidazo[1,2-a]Benzimidazole Dinitrate and Determination of the Main Metabolite in Blood Serum of Laboratory Animals.
- Authors
Mitrakova, D. O.; Chernikov, M. V.; Remezova, I. P.; Bunyatyan, N. D.; Morozov, A. V.
- Abstract
Urinary excretion of 9-(2-diethylaminoethyl)-2-phenylimidazo[1,2-a]benzimidazole dinitrate after intragastric administration at a dose of 10 mg/kg has been studied in laboratory rats. The main metabolite in blood serum of rats was determined after a single intravenous injection at a dose of 10 mg/kg. The metabolite was determined in urine samples using HPLC. Its structure was established using HPLC-MS. According to the results, the drug substance was excreted unchanged in small amounts (~0.01% of the administered dose) because it was metabolized. The main metabolite was found in rat plasma as early as 3 min after intravenous injection at a dose of 10 mg/kg.
- Subjects
LABORATORY animals; LABORATORY rats; EXCRETION; INTRAVENOUS injections; HIGH performance liquid chromatography
- Publication
Pharmaceutical Chemistry Journal, 2022, Vol 56, Issue 8, p1027
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-022-02747-3