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- Title
Synthesis and Antiproliferative Activity of New N-Acylhydrazone Derivatives Containing Benzothiazole and Indole Based Moiety.
- Authors
Liu, Kai; Ding, Yangyang; Kang, Congmin
- Abstract
Through a structure-based molecular hybridization strategy, a series of new N-acylhydrazone derivatives containing the benzothiazole and indole based moiety were designed, synthesized and screened for in vitro antiproliferative activity against Hep G2 cancer cell line. One compound (7a) exhibited excellent antiproliferative activity with IC50 values of 0.78 μM against Hep G2. In addition, C-5 substitutions of the indole ring of target compounds might be crucial for their cytotoxic activities. Additionally, the relative configuration of target compounds was confirmed as the E isomer. Further chemical manipulation of derivative 7a can make it possible to obtain new potential antitumor agents.
- Subjects
BENZOTHIAZOLE derivatives; MOIETIES (Chemistry); MOLECULAR hybridization; CHEMICAL derivatives; CYCLIC compounds; INDOLE
- Publication
Pharmaceutical Chemistry Journal, 2020, Vol 54, Issue 4, p345
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-020-02215-w