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- Title
Regulatory impact factors: unraveling the transcriptional regulation of complex traits from expression data.
- Authors
Reverter, Antonio; Hudson, Nicholas J.; Nagaraj, Shivashankar H.; Pérez-Enciso, Miguel; Dalrymple, Brian P.
- Abstract
Motivation: Although transcription factors (TF) play a central regulatory role, their detection from expression data is limited due to their low, and often sparse, expression. In order to fill this gap, we propose a regulatory impact factor (RIF) metric to identify critical TF from gene expression data.
- Subjects
TRANSCRIPTION factors; GENE expression; GENETIC regulation; PROTEINS; GENETICS
- Publication
Bioinformatics, 2010, Vol 26, Issue 7, p896
- ISSN
1367-4803
- Publication type
Article
- DOI
10.1093/bioinformatics/btq051