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- Title
Adipocyte browning and resistance to obesity in mice is induced by expression of ATF3.
- Authors
Cheng, Ching-Feng; Ku, Hui-Chen; Cheng, Jing-Jy; Chao, Shi-Wei; Li, Hsiao-Fen; Lai, Pei-Fang; Chang, Che-Chang; Don, Ming-Jaw; Chen, Hsi-Hsien; Lin, Heng
- Abstract
Billions of people have obesity-related metabolic syndromes such as diabetes and hyperlipidemia. Promoting the browning of white adipose tissue has been suggested as a potential strategy, but a drug still needs to be identified. Here, genetic deletion of activating transcription factor 3 (ATF3−/−) in mice under a high-fat diet (HFD) resulted in obesity and insulin resistance, which was abrogated by virus-mediated ATF3 restoration. ST32da, a synthetic ATF3 inducer isolated from Salvia miltiorrhiza, promoted ATF3 expression to downregulate adipokine genes and induce adipocyte browning by suppressing the carbohydrate-responsive element-binding protein–stearoyl-CoA desaturase-1 axis. Furthermore, ST32da increased white adipose tissue browning and reduced lipogenesis in HFD-induced obese mice. The anti-obesity efficacy of oral ST32da administration was similar to that of the clinical drug orlistat. Our study identified the ATF3 inducer ST32da as a promising therapeutic drug for treating diet-induced obesity and related metabolic disorders. Ching-Feng Cheng et al. find that expression of the transcription factor ATF3 in mice provides protection from obesity and insulin resistance under a high-fat diet. They show that expression of ATF3 can be induced by ST32da, a compound derived from the Chinese sage plant, Salvia miltiorrhiza.
- Subjects
FAT cells; OBESITY; METABOLIC syndrome; HYPERLIPIDEMIA; SALVIA miltiorrhiza
- Publication
Communications Biology, 2019, Vol 2, Issue 1, pN.PAG
- ISSN
2399-3642
- Publication type
Article
- DOI
10.1038/s42003-019-0624-y