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- Title
Linkage disequilibrium and association with methamphetamine dependence/psychosis of μ-opioid receptor gene polymorphisms.
- Authors
Ide, S.; Kobayashi, H.; Ujike, H.; Ozaki, N.; Sekine, Y.; Inada, T.; Harano, M.; Komiyama, T.; Yamada, M.; Iyo, M.; Iwata, N.; Tanaka, K.; Shen, H.; Iwahashi, K.; Itokawa, M.; Minami, M.; Satoh, M.; Ikeda, K.; Sora, I.
- Abstract
Several studies indicate that the μ-opioid receptor plays a role in addiction not only to opiate drugs but also to alcohol and non-opiate addictive drugs. Our studies aim to reveal the associations between gene polymorphisms and methamphetamine (MAP) dependence/psychosis. We newly identified several polymorphisms and four substantial linkage disequilibrium (LD) blocks in the μ-opioid receptor (OPRM1) gene. We found significant differences in both genotype and allele frequencies of the single-nucleotide polymorphism (SNP) IVS2+G691C between control (n=232) and MAP-dependent/psychotic patients (n=128). There was also a significant association between IVS2+G691C and patients with transient psychosis. These results suggest that the OPRM1 gene variations may be a factor in development and prognosis of MAP psychosis.The Pharmacogenomics Journal (2006) 6, 179–188. doi:10.1038/sj.tpj.6500355; published online 10 January 2006
- Subjects
METHAMPHETAMINE abuse; PSYCHOSES; OPIOID receptors; GENETIC polymorphisms; NUCLEOTIDES
- Publication
Pharmacogenomics Journal, 2006, Vol 6, Issue 3, p179
- ISSN
1470-269X
- Publication type
Article
- DOI
10.1038/sj.tpj.6500355