We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Microwave‐Assisted Diversity‐Oriented Synthesis of Thiazol‐2(3H)‐ones and Its Interaction with Biomacromolecules.
- Authors
Preeti; Kumar, Mahesh; Jaiswal, Anjali; Nand Singh, Krishna
- Abstract
An expeditious catalyst‐free heteroannulation has been accomplished to access functionalized thiazol‐2(3H)‐ones by the reaction of isothiocyanates and 2‐bromoketones in EtOH under controlled microwave irradiation heating. The synthetic strategy is simple, straightforward, and offers two points of structural diversity to expand the product versatility. Further, the biological relevance of the synthesized thiazol‐2(3H)‐ones has been examined for their possible use as putative acetylcholinesterase inhibitors through molecular docking analysis.
- Subjects
BIOMACROMOLECULES; MICROWAVE heating; MOLECULAR docking; ACETYLCHOLINESTERASE inhibitors; ISOTHIOCYANATES
- Publication
Asian Journal of Organic Chemistry, 2022, Vol 11, Issue 2, p1
- ISSN
2193-5807
- Publication type
Article
- DOI
10.1002/ajoc.202100389