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- Title
Discriminatory performance of insulin-like growth factor 1 and insulin-like growth factor binding protein- 3 by correlating values to chronological age, bone age, and pubertal status for diagnosis of isolated growth hormone deficiency.
- Authors
Yu Jung Choi; Yoon Ji Lee; Na Yeong Lee; Seon-Hwa Lee; Seul-Ki Kim; Moon-Bae Ahn; Shin-Hee Kim; Won-Kyoung Cho; Kyoung-Soon Cho; Min Ho Jung; Byung-Kyu Suh
- Abstract
Purpose: The discriminatory performance of insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) was investigated by correlating their values with chronological age (CA), bone age (BA), and pubertal status (PS) for diagnosis of isolated growth hormone deficiency (IGHD). Methods: We evaluated IGF-1 and IGFBP-3 levels in 310 short-stature subjects subdivided into 2 groups: IGHD (n=31) and non-IGHD (n=279). IGF-1 and IGFBP-3 were assayed using immune-radiometric assay and transformed into standard deviation score (SDS) according to CA, BA, and PS. Results: The highest sensitivity was found in IGF-1-SDS for CA and IGFBP-3-SDS for CA (22.6% and 30.0%, respectively). The highest specificity was found in IGF-1-SDS for PS and IGFBP-3-SDS for PS (98.2% and 94.4%, respectively). Groups with the highest positive predictive values were IGF-1-SDS for BA and IGFBP-3-SDS for BA (10.9% and 5.1%, respectively). Highest negative predictive values were seen in IGF- 1-SDS for CA and IGFBP-3-SDS for CA (98.4% and 98.4%, respectively). Conclusion: IGF-1-SDS for CA, instead of IGF-1-SDS for BA or PS, could be used as a standard variable for IGHD screening. The sufficiently high specificity of IGF-1-SDS for PS suggests that this value is a useful tool for identification of IGHD.
- Subjects
SOMATOMEDIN C; SOMATOMEDIN; AGE; DIAGNOSIS; PITUITARY dwarfism; HYPOPITUITARISM
- Publication
Annals of Pediatric Endocrinology & Metabolism, 2020, Vol 25, Issue 4, p240
- ISSN
2287-1012
- Publication type
Article
- DOI
10.6065/apem.2040018.009