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- Title
Posterior Reversible Encephalopathy Syndrome in Children: Case Series and Systematic Review.
- Authors
Chen, Tai-Heng; Lin, Wei-Chen; Tseng, Yong-Hao; Tseng, Chien-Ming; Chang, Tai-Tsung; Lin, Tzeng-Jih
- Abstract
To study presentations and outcome of posterior reversible encephalopathy syndrome in children, we retrospectively analyzed 14 patients admitted to our pediatric intensive care unit. We further assessed 94 additional pediatric cases from a systematic review. Our patients had a mean age of 11.6 years. Their precipitating factors were hypertension (100%), immunosuppressants (71%), antineoplastic agents (21%), and hemodialysis (14%). Initial neurologic manifestations included seizures (100%), mental change (100%), headache (79%), and visual disturbance (57%). After prompt diagnosis by magnetic resonance imaging (MRI) with intensive management, all patients had complete clinical recovery with subsequent radiologic resolution. Systemic literature review indicated that seizures (90%), hypertension (85%), and atypical neuroimaging findings (80%) are common presentations in childhood posterior reversible encephalopathy syndrome. We conclude that in children presenting with seizures and hypertension, a pediatric neurologist should consider posterior reversible encephalopathy syndrome within a comprehensive differential diagnosis of acute encephalopathy. Early recognition and intensive care are essential to ensure complete neurologic recovery in children with posterior reversible encephalopathy syndrome.
- Subjects
POSTERIOR leukoencephalopathy syndrome; HYPERTENSIVE encephalopathy; MAGNETIC resonance imaging; PEDIATRIC intensive care; HYPERTENSION in children; IMMUNOSUPPRESSIVE agents
- Publication
Journal of Child Neurology, 2013, Vol 28, Issue 11, p1378
- ISSN
0883-0738
- Publication type
Article
- DOI
10.1177/0883073813500714