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- Title
N-acetylcysteine for hepatic veno-occlusive disease after allogeneic stem cell transplantation.
- Authors
Ringdén, O; Remberger, M; Lehmann, S; Hentschke, P; Mattsson, J; Klaesson, S; Aschan, J
- Abstract
Three patients developed veno-occlusive disease of the liver (VOD) after allogeneic stem cell transplantation. On the day after diagnosis, N-acetylcysteine (NAC) was given, initially in loading doses and thereafter 50–150 mg/kg/day for 12 to 31 days. The maximum bilirubin levels were 137, 58 and 138 mmol/l in the three patients, respectively. After the introduction of NAC, bilirubin, aspertate aminotransferase, sIL-2 receptor and IL-8 decreased. All three patients achieved normal bilirubin levels and prothrombin times. To conclude, NAC may be useful for treatment of VOD. Bone Marrow Transplantation (2000) 25, 993–996.
- Subjects
STEM cell transplantation; LIVER diseases; BILIRUBIN
- Publication
Bone Marrow Transplantation, 2000, Vol 25, Issue 9, p993
- ISSN
0268-3369
- Publication type
Article