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- Title
ANTIPROLIFERATIVE ACTIVITY OF ANNONA SQUAMOSA L. FRACTIONS ON HUMAN TUMOR CELL LINES.
- Authors
GOMES GUIDOTI, DANIELA GRANELLA; TEIXEIRA GUIDO, DAVID; LOPES ROMERO, ADRIANO; TASCA GOIS RUIZ, ANA LÚCIA; FOGLIO, MARY ANN; DE CARVALHO, JOÃO ERNESTO; DE MELLO SARTORI CARDOSO DA ROCHA, CARMEM LÚCIA
- Abstract
Annona squamosa Linn.(Annonaceae) is a rich source of bioactive compounds, such as alkaloids, tannin, phenolic compounds, aromatic plyketides, steroids, diterpenes and mineral components. Several parts of this plant are traditionally used in the treatment of diabetes and cancer. The current assay evaluates antiproliferative activity of fractions of sugarapple (A. squamosa) peel and seeds in nine human tumor cell lines (K562, HT29, PC3, NCIH460, MCF7, NCIADR/RES, UACC62, U251 e 7860) and in a nontumor cell line (HaCat), with doxorubicin as positive control. Cell differentiation was determined by spectrophometric quantification. Seed and peel fractions showed cytostatic and cytocidal effects on cell lines at different concentrations, except for K562. All fractions were selective for the NCIH460 strain. However, other fractions had an antiproliferative effect on the other strains, especially on the methanol fraction of seeds, which showed the highest cytocidal percentage (up to 100%). Results indicate the potential of these fractions as sources of new chemotherapeutic and/or chemopreventive agents to be isolated and identified.
- Subjects
CELL lines; PHENOLS; CELL differentiation; BIOACTIVE compounds; ANNONA
- Publication
Journal of Neotropical Biology / Revista de Biologia Neotropical, 2024, Vol 21, Issue 1, p17
- ISSN
1807-9652
- Publication type
Article
- DOI
10.5216/rbn