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- Title
Hyperspectral Imaging for Non-invasive Diagnostics of Melanocytic Lesions.
- Authors
PAOLI, John; PÖLÖNEN, Ilkka; SALMIVUORI, Mari; RÄSÄNEN, Janne; ZAAR, Oscar; POLESIE, Sam; KOSKENMIES, Sari; PITKÄNEN, Sari; ÖVERMARK, Meri; ISOHERRANEN, Kirsi; JUTEAU, Susanna; RANKI, Annamari; GRÖNROOS, Mari; NEITTAANMÄKI, Noora
- Abstract
Malignant melanoma poses a clinical diagnostic problem, since a large number of benign lesions are excised to find a single melanoma. This study assessed the accuracy of a novel non-invasive diagnostic technology, hyperspectral imaging, for melanoma detection. Lesions were imaged prior to excision and histopathological analysis. A deep neural network algorithm was trained twice to distinguish between histopathologically verified malignant and benign melanocytic lesions and to classify the separate subgroups. Furthermore, 2 different approaches were used: a majority vote classification and a pixel-wise classification. The study included 325 lesions from 285 patients. Of these, 74 were invasive melanoma, 88 melanoma in situ, 115 dysplastic naevi, and 48 non-dysplastic naevi. The study included a training set of 358,800 pixels and a validation set of 7,313 pixels, which was then tested with a training set of 24,375 pixels. The majority vote classification achieved high overall sensitivity of 95% and a specificity of 92% (95% confidence interval (95% CI) 0.024-0.029) in differentiating malignant from benign lesions. In the pixel-wise classification, the overall sensitivity and specificity were both 82% (95% CI 0.005-0.005). When divided into 4 subgroups, the diagnostic accuracy was lower. Hyperspectral imaging provides high sensitivity and specificity in distinguishing between naevi and melanoma. This novel method still needs further validation.
- Subjects
MAJORITIES; MELANOMA; DYSPLASTIC nevus syndrome; PLURALITY voting; SENSITIVITY &; specificity (Statistics)
- Publication
Acta Dermato-Venereologica, 2022, Vol 102, p1
- ISSN
0001-5555
- Publication type
Article
- DOI
10.2340/actadv.v102.2045