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- Title
Near-Infrared Analysis of Hydrogen-Bonding in Glass- and Rubber-State Amorphous Saccharide Solids.
- Authors
Izutsu, Ken-ichi; Hiyama, Yukio; Yomota, Chikako; Kawanishi, Toru
- Abstract
Near-infrared (NIR) spectroscopic analysis of noncrystalline polyols and saccharides (e.g., glycerol, sorbitol, maltitol, glucose, sucrose, maltose) was performed at different temperatures (30–80°C) to elucidate the effect of glass transition on molecular interaction. Transmission NIR spectra (4,000–12,000 cm−1) of the liquids and cooled-melt amorphous solids showed broad absorption bands that indicate random configuration of molecules. Heating of the samples decreased an intermolecular hydrogen-bonding OH vibration band intensity (6,200–6,500 cm−1) with a concomitant increase in a free and intramolecular hydrogen-bonding OH group band (6,600–7,100 cm−1). Large reduction of the intermolecular hydrogen-bonding band intensity at temperatures above the glass transition ( T g) of the individual solids should explain the higher molecular mobility and lower viscosity in the rubber state. Mixing of the polyols with a high T g saccharide (maltose) or an inorganic salt (sodium tetraborate) shifted both the glass transition and the inflection point of the hydrogen-bonding band intensity to higher temperatures. The implications of these results for pharmaceutical formulation design and process monitoring (PAT) are discussed.
- Publication
AAPS PharmSciTech, 2009, Vol 10, Issue 2, p524
- ISSN
1530-9932
- Publication type
Article
- DOI
10.1208/s12249-009-9243-0