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- Title
A randomized, placebo-controlled trial of monthly azithromycin prophylaxis to prevent sexually transmitted infections and HIV-1 in Kenyan sex workers: study design and baseline findings.
- Authors
Fonck, K.; Kaul, R.; Kimani, J.; Keli, F.; MacDonald, K. S.; Ronald, A. R.; Plummer, F. A.; Kirui, P.; Bwayo, J. J.; Ngugi, E. N.; Moses, S.; Temmerman, M.
- Abstract
Our objectives were to describe the baseline findings of a trial of antibiotic prophylaxis to prevent sexually transmitted infections (STIs) and HIV-1 in a cohort of Nairobi female sex workers (FSWs). A questionnaire was administered and a medical examination was performed. HIV-negative women were randomly assigned to either one gram azithromycin or placebo monthly. Mean age of the 318 women was 32 years, mean duration of sex work 7 years and mean number of clients was 4 per day. High-risk behaviour was frequent: 14% practised anal intercourse, 23% sex during menses, and 3% used intravenous drugs. While 20% reported condom use with all clients, 37% never use condoms. However, STI prevalence was relatively low: HIV-1 27%, bacterial vaginosis 46%, Trichomonas vaginalis 13%, Neisseria gonorrhoeae 8%, Chlamydia trachomatis 7%, syphilis 6% and cervical intraepithelial neoplasia (CIN) 3%. It appears feasible to access a population of high-risk FSWs in Nairobi with prevention programmes, including a proposed trial of HIV prevention through STI chemoprophylaxis.
- Subjects
NAIROBI (Kenya); KENYA; AZITHROMYCIN; HIV infections; SEXUALLY transmitted diseases; SEX workers; ANTIBACTERIAL agents; AIDS prevention
- Publication
International Journal of STD & AIDS, 2000, Vol 11, Issue 12, p804
- ISSN
0956-4624
- Publication type
journal article
- DOI
10.1258/0956462001915327