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- Title
The effect of phytic acid on enzymatic degradation of dentin.
- Authors
Forgione, Diletta; Nassar, Mohannad; Seseogullari‐Dirihan, Roda; Thitthaweerat, Suppason; Tezvergil‐Mutluay, Arzu
- Abstract
We evaluated the effect of phytic acid on matrix metalloproteinase (MMP)‐ or cysteine cathepsin (CC)‐mediated dentin degradation. Demineralized dentin beams were divided into five groups (n = 12) and treated with 1%, 2%, or 3% phytic acid or with 37% phosphoric acid. Untreated demineralized beams served as controls. After incubation for 1 or 3 wk, dry mass loss was determined and aliquots of incubation media were analysed for cross‐linked telopeptide of type I collagen (ICTP) fragments for MMP‐mediated and c‐terminal telopeptide of type I collagen (CTX) for cathepsin‐k‐mediated degradation. The direct effect of phytic acid was evaluated using MMP activity assay. Data were analysed using repeated‐measures anova. ICTP releases with 1% and 2% phytic acid treatment were statistically significantly lower than those following phosphoric acid treatment at 3 wk. The CTX release for phytic acid‐treated beams at 3 wk was not significantly different from that of untreated control beams, but it was significantly lower than that of phosphoric acid‐treated beams. Their MMP activities at 3 wk were not significantly different from those of the controls but they were significantly lower than those seen for phosphoric acid‐treated beams. Compared to phosphoric acid, phytic acid treatment resulted in a reduced dentinal host‐derived endogenous enzymatic activity and collagen degradation.
- Subjects
DENTIN; PHOSPHORIC acid; ANALYSIS of variance; PHYTIC acid; MATRIX metalloproteinases; DESCRIPTIVE statistics; REPEATED measures design
- Publication
European Journal of Oral Sciences, 2021, Vol 129, Issue 2, p1
- ISSN
0909-8836
- Publication type
Article
- DOI
10.1111/eos.12771