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- Title
Maternal and perinatal outcomes in pregnant women with BMI >50: An international collaborative study.
- Authors
McCall, Stephen J.; Li, Zhuoyang; Kurinczuk, Jennifer J.; Sullivan, Elizabeth; Knight, Marian
- Abstract
Objective: To examine the association between maternal BMI>50kg/m2 during pregnancy and maternal and perinatal outcomes. Materials and methods: An international cohort study was conducted using data from separate national studies in the UK and Australia. Outcomes of pregnant women with BMI>50 were compared to those of pregnant women with BMI<50. Multivariable logistic regression estimated the association between BMI>50 and perinatal and maternal outcomes. Results: 932 pregnant women with BMI>50 were compared with 1232 pregnant women with BMI<50. Pregnant women with BMI>50 were slightly older, more likely to be multiparous, and have pre-existing comorbidities. There were no maternal deaths, however, extremely obese women had a nine-fold increase in the odds of thrombotic events compared to those with a BMI<50 (uOR: 9.39 (95%CI:1.15–76.43)). After adjustment, a BMI>50 during pregnancy had significantly raised odds of preeclampsia/eclampsia (aOR:4.88(95%CI: 3.11–7.65)), caesarean delivery (aOR: 2.77 (95%CI: 2.31–3.32)), induction of labour (aOR: 2.45(95% CI:2.00–2.99)) post caesarean wound infection (aOR:7.25(95%CI: 3.28–16.07)), macrosomia (aOR: 8.05(95%CI: 4.70–13.78)) compared a BMI<50. Twelve of the infants born to women in the extremely obese cohort died in the early neonatal period or were stillborn. Conclusions: Pregnant women with BMI>50 have a high risk of inferior maternal and perinatal outcomes.
- Subjects
BODY mass index; MATERNAL health; LOGISTIC regression analysis; MATERNAL mortality; CESAREAN section
- Publication
PLoS ONE, 2019, Vol 14, Issue 2, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0211278