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- Title
Disease-modifying effects of postexposure hepatitis A active immunization.
- Authors
Mimouni D; Bar-Zeev Y; Davidovitch N; Zarka S; Mimouni, Daniel; Bar-Zeev, Yael; Davidovitch, Nadav; Zarka, Salman
- Abstract
<bold>Background: </bold>Several studies have demonstrated the efficacy of hepatitis A virus (HAV) active vaccine in the prevention of secondary HAV infection when administered shortly after exposure.<bold>Methods: </bold>We describe six new recruits with unknown HAV infection, of whom three received late postexposure prophylaxis with the active HAV vaccine and three were not vaccinated.<bold>Results: </bold>Results indicated that the vaccinated patients had a longer period from exposure to onset of symptoms (p < 0.05), shorter hospitalization, and lower liver enzyme levels.<bold>Conclusions: </bold>It appears that late administration of the active HAV vaccine has a disease-modifying effect. These findings, combined with earlier reports, may have important implications for immunization policies.
- Publication
Military Medicine, 2006, Vol 171, Issue 12, p1196
- ISSN
0026-4075
- Publication type
journal article
- DOI
10.7205/milmed.171.12.1196