We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Single Oral Administration of Pilsicainide Versus Infusion of Disopyramide for Termination of Paroxysmal Atrial Fibrillation: A Multicenter Trial.
- Authors
Kumagai, Koichiro; Abe, Haruhiko; Hiraki, Tatsuro; Nakashima, Hideko; Oginosawa, Yasushi; Ikeda, Hisao; Nakashima, Yasuhide; Imaizumi, Tsutomu; Saku, Keijiro
- Abstract
A single oral dose of pilsicainide (PLS) is effective in terminating acute-onset atrial fibrillation (AF). However, the effectiveness of this single oral treatment has not been compared with the infusion of other antiarrhythmic drugs. The effects of a single oral dose of PLS on the termination of AF were compared with an infusion of disopyramide (DISO) in a multicenter trial. Seventy-two patients with electrocardiographically confirmed, symptomatic, paroxysmal AF (< 48-hour duration) were randomized to receive either a single 100- to 150-mg dose of PLS versus a 2 mg/kg (maximum dose = 100 mg) infusion of DISO. Successful defibrillation was defined as termination of AF within 2 hours of drug administration. Conversion of AF to sinus rhythm was achieved within 2 hours in 29 of 40 patients (73%) treated with PLS, and in 28 of 32 patients (56%) treated with DISO (NS). The mean time to return of sinus rhythm was 60 ± 30 minutes in the PLS group versus 23 ± 18 minutes in the DISO group (P < 0.001). DISO was particularly effective in terminating nocturnal AF, whereas PLS had a stable circadian effect, PLS was significantly mare effective than DISO between 6 AM and 12 PM (64% vs 17%, P < 0.05). No adverse effect was observed in either group. In conclusion, a single oral dose of PLS was as effective as an infusion of DISO to restore sinus rhythm in patients with recent- onset AF. PLS consistently terminated AF regardless a fits time of onset.
- Subjects
ATRIAL fibrillation; MYOCARDIAL depressants; DISOPYRAMIDE; ELECTROCARDIOGRAPHY; DRUG administration; CLINICAL trials
- Publication
Pacing & Clinical Electrophysiology, 2000, Vol 23, Issue 11, p1880
- ISSN
0147-8389
- Publication type
Article
- DOI
10.1111/j.1540-8159.2000.tb07043.x