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- Title
Soft tissue healing around platform-switching and platform-matching single implants: A randomized clinical trial.
- Authors
Cheng, Guo‐Liang; Leblebicioglu, Binnaz; Li, Jianrong; Chien, Hua‐Hong; Cheng, Guo-Liang; Chien, Hua-Hong
- Abstract
<bold>Background: </bold>Implants with platform-switching (PS) design have been demonstrated to reduce marginal bone loss. However, the influence on peri-implant soft tissue healing is unclear. This study was designed to investigate its effect on peri-implant soft tissue healing after implant uncovery.<bold>Methods: </bold>Non-smokers needing two implants in different quadrants were recruited in this study. For each individual, one PS and one platform-matching (PM) implants were placed using two-stage protocol. Following 2 to 8 months of healing, all implants were uncovered and connected to the corresponding healing abutments. Clinical measurements and peri-implant crevicular fluid (PICF) were taken at 1-, 2-, 4-, and 6-week after 2nd stage surgery. The cytokine concentrations in PICF were analyzed. Peri-implant mucosa (1 × 2 × 2 mm) was harvested around the healing abutment for the analysis of gene expression at uncovery and 6-week post-uncovery.<bold>Results: </bold>Eighteen participants (nine males; 51.7 ± 14.9 years) were recruited. Compared to PM, PS showed significantly lower probing depth (PD) at 1- and 2-week as well as modified sulcus bleeding index (mSBI) at 1-, 4-, and 6-week (P < 0.05). Over time, a decrease in osteoprotegerin and interleukin-1β concentrations in PICF along with an increase in receptor activator of unclear factor kappa-B ligand, periostin, and peroxidasin gene expressions in peri-implant mucosa were noted within both groups (P < 0.05) without significant intergroup differences.<bold>Conclusion: </bold>Within the limits, implants with PS design rendered significant benefits over PM design in PD and mSBI reduction during a 6-week healing. However, molecular changes within PICF and peri-implant mucosa as a response to PM and PS appear negligible.
- Subjects
WOUND healing; DENTAL implants; GINGIVAL fluid; CYTOKINES; GENE expression; RESEARCH; RESEARCH methodology; EVALUATION research; MEDICAL cooperation; COMPARATIVE studies; RANDOMIZED controlled trials
- Publication
Journal of Periodontology, 2020, Vol 91, Issue 12, p1609
- ISSN
0022-3492
- Publication type
journal article
- DOI
10.1002/JPER.20-0030