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- Title
A Speckle-Free Angular Interrogation SPR Imaging Sensor Based on Galvanometer Scan and Laser Excitation.
- Authors
Zeng, Youjun; Zhou, Jie; Xiao, Xiaoping; Wang, Lei; Qu, Junle; Li, Xuejin; Gao, Bruce Zhi; Shao, Yonghong
- Abstract
A speckle-free fast angular interrogation surface plasmon resonance imaging (SPRi) sensor based on a diode-pumped all-solid-state laser and galvanometer is reported in this work. A bidirectional scan using a galvanometer realizes the fast scanning of the incidence angle. The experimental results showed that the time needed for completing an SPR dip measurement was decreased to 0.5 s. And through cascading an immovable diffuser and two diffusers rotating in opposite directions, laser speckle was eliminated. The dynamic detection range and the sensitivity reached 4.6 × 10−2 and 1.52 × 10−6 refractive index unit (RIU), respectively, in a 2D array sensor when the angle scanning range was set as 7.5°. More importantly, the results demonstrated that the angular interrogation SPR imaging sensor scheme had the capability to perform fast and high-throughput detection of biomolecular interactions at 2D sensor arrays.
- Subjects
IMAGE sensors; SURFACE plasmon resonance; QUESTIONING; SENSOR arrays; SPECKLE interference; SOLID-state lasers; AIRBORNE lasers
- Publication
Plasmonics, 2019, Vol 14, Issue 6, p1497
- ISSN
1557-1955
- Publication type
Article
- DOI
10.1007/s11468-019-00938-5