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- Title
Cardiovascular effects of arginase inhibition in spontaneously hypertensive rats with fully developed hypertension.
- Authors
Bagnost, Teddy; Ling Ma; Da Silva, Rafaela F.; Rezakhaniha, Rana; Houdayer, Christophe; Stergiopulos, Nikos; André, Claire; Guillaume, Yves; Berthelot, Alain; Demougeot, Céline
- Abstract
Aims: Growing evidence suggests that arginase misregulation plays a key role in the pathophysiology of essential hypertension. In the present study, we investigated the potential cardiovascular therapeutic effects of a long-term treatment with an arginase inhibitor in adult spontaneously hypertensive rats (SHR) with fully developed hypertension.
- Subjects
ARTERIES; PATHOLOGICAL physiology; ESSENTIAL hypertension; HYPERTENSION; LABORATORY rats
- Publication
Cardiovascular Research, 2010, Vol 87, Issue 3, p569
- ISSN
0008-6363
- Publication type
Article
- DOI
10.1093/cvr/cvq081