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- Title
Recycling endosomes supply cardiac pacemaker channels for regulated surface expression.
- Authors
Hardel, Nadine; Harmel, Nadine; Zolles, Gerd; Fakler, Bernd; Klöker, Nikolaj
- Abstract
Aims: Cellular excitability is not only determined by the type but also by the number of ion channels in the plasma membrane. Recent evidence indicates that cell surface expression of cardiac pacemaker channels might be controlled beyond the level of biosynthesis by regulating their surface transport. However, neither the underlying trafficking pathways nor their molecular control have yet been investigated.
- Subjects
ENDOSOMES; CARDIAC pacemakers; PHOSPHOLIPASES; ANGIOTENSINS; IMPLANTED cardiovascular instruments
- Publication
Cardiovascular Research, 2008, Vol 79, Issue 1, p52
- ISSN
0008-6363
- Publication type
Article
- DOI
10.1093/cvr/cvn062