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- Title
Toll-like receptor 2 gene polymorphisms in Korean women with human papillomavirus-related cervical neoplasia.
- Authors
Kim, Jin Hwi; Key, Eun Young; Song, Min Jong; Lee, Sung Jong; Kim, Chan Joo; Hur, Soo Young; Park, Tae Chul; Kim, Tae Gyu; Park, Jong Sup
- Abstract
<bold>Introduction: </bold>The aim of this study was to investigate the association between Toll-like receptor 2 (TLR2) gene polymorphisms and human papillomavirus (HPV)-related cervical neoplasia in Korean women.<bold>Material and Methods: </bold>Peripheral blood samples collected from 127 patients with HPV-related cervical neoplasia and 175 healthy women were genotyped for the TLR2 -16934, +1350, intron1, and 3' untranslated region (UTR) polymorphisms using the polymerase chain reaction and restriction fragment length polymorphism method.<bold>Results: </bold>The TLR2 -16934 A/A, intron1 A/A, and +1350 T/C genotypes were more frequent in patients than in controls [odds ratio (OR) = 2.1, 95% CI = 1.302-3.475, p = 0.002; OR = 1.9, 95% CI = 1.168-3.169, p = 0.010; and OR = 1.9, 95% CI = 1.211-3.123, p = 0.006, respectively]. The frequencies of the TLR2 + 1350 C and 3'UTR G alleles were also higher in patients (OR = 2.0, 95% CI = 1.236-3.121, p = 0.004 and OR = 1.7, 95% CI = 1.005-3.076, p = 0.046, respectively). The genotype frequencies of TLR2 -16934 A/A and intron1 A/A increased with increasing oncogenic risk of the HPV genotype, as follows. low-risk type < high-risk type < HPV-16 and/or HPV-18 type (p = 0.008).<bold>Conclusions: </bold>Our study provides the first evidence that TLR2 gene polymorphisms are associated with high-risk type HPV-related cervical neoplasia and may play an important role in susceptibility to HPV infection. Further large-scale and functional studies are needed to confirm the role of TLR2 gene polymorphisms in HPV-related cervical neoplasia.
- Subjects
KOREA; SOUTH Korea; GENETIC polymorphisms; WOMEN; PAPILLOMAVIRUSES; CERVICAL intraepithelial neoplasia; BLOOD sampling; ASIANS; CELL receptors; PAPILLOMAVIRUS diseases; CERVIX uteri tumors; CASE-control method; GENOTYPES
- Publication
Acta Obstetricia et Gynecologica Scandinavica, 2016, Vol 95, Issue 7, p829
- ISSN
0001-6349
- Publication type
journal article
- DOI
10.1111/aogs.12895