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- Title
FOXO3a and ?-catenin co-localization: double trouble in colon cancer?
- Authors
Yan, Yibing; Lackner, Mark R
- Abstract
The article discusses the role of Forkhead box O3a and βcatenin protein in promoting metastatic colorectal cancer. Forkhead box O3a is a transcriptional regulator of the phosphoinositide 3-kinase-AKT signaling which arrest cell cycle and promotes apoptosis. AKT pathway inhibition releases FOXO3a protein to translocate to the nucleus where it can regulate the expression of gene.
- Subjects
COLON cancer; METASTASIS; CATENINS; PROTEIN kinase B regulation; GENE expression; APOPTOSIS
- Publication
Nature Medicine, 2012, Vol 18, Issue 6, p854
- ISSN
1078-8956
- Publication type
Article
- DOI
10.1038/nm.2799