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- Title
Insight from the Air-Skin Interface.
- Authors
O'Shaughnessy, Ryan F L; Brown, Sara J
- Abstract
The epidermis is a relatively hypoxic tissue, despite being continually exposed to air. The role of hypoxia in epidermal differentiation and skin barrier function is incompletely understood. In this issue, Wong et al. show that hypoxia-inducible factors are central to the processes of epidermal differentiation and barrier formation, in particular by promoting the expression of the key skin barrier protein filaggrin.
- Subjects
HYPOXIA-inducible factors; EPIDERMAL diseases; SKIN permeability; GENE expression; GENE targeting; PROTEIN expression; FILAGGRIN; THERAPEUTICS
- Publication
Journal of Investigative Dermatology, 2015, Vol 135, Issue 2, p331
- ISSN
0022-202X
- Publication type
Article
- DOI
10.1038/jid.2014.457