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- Title
Tumor Necrosis Factor-α and Apoptosis Induction in Melanoma Cells through Histone Modification by 3-Deazaneplanocin A.
- Authors
Tanaka, Ryo; Donovan, Nicholas C; Yu, Qiang; Irie, Reiko F; Hoon, Dave S B
- Abstract
The article discusses a study about the induction of tumor necrosis factor a and apoptosis in melanoma cells through histone modification by 3-Deazaneplanocin A (DZNep). An overview about the characteristics of malignant melanoma and TNF-a is provided. The study reveals that DZNep treatment induced apoptosis in melanoma cells.
- Subjects
TUMOR necrosis factors; CYTOKINES; MELANOMA; NEUROENDOCRINE tumors; APOPTOSIS; CELL death
- Publication
Journal of Investigative Dermatology, 2014, Vol 134, Issue 5, p1470
- ISSN
0022-202X
- Publication type
Article
- DOI
10.1038/jid.2013.489