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- Title
Electrophysiologic Properties of Nitroprusside in Man.
- Authors
Gould, Lawrence; Reddy, C. V. Ramana; Kim, S. G.; Oh, K. C.
- Abstract
The effects of nitroprusside on His bundle electrograms, when given intravenously for 10 minutes, were studied in 14 patients with heart disease. Recordings were made at varied heart rates using atrial and ventricular pacing. Nitroprusside significantly reduced the AH interval, but it had no effect on the HV interval. Functional and effective refractory periods were measured by the extrastimulus technique. The functional refractory period of the AV node as well as the effective refractory period of the ventriculoatrial conduction system significantly decreased after nitroprusside infusion. This improvement in conduction can probably be explained by the systemic hypotension produced by nitroprusside, which reflexly will increase sympathetic drive to the heart and decrease vagal tone.
- Subjects
SODIUM nitroferricyanide; ELECTROPHYSIOLOGY; APLASTIC anemia; HEART beat; HYPOTENSION; BLOOD circulation disorders
- Publication
Angiology, 1979, Vol 30, Issue 12, p841
- ISSN
0003-3197
- Publication type
Article
- DOI
10.1177/000331977903001208