We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Variability of four nutrients evaluated in adult multivitamin/mineral (MVM) products.
- Authors
Schweitzer, Amy; Andrews, Karen; Roseland, Janet; Cuiwei Zhao; Holden, Joanne; Perry, Charles; Douglass, Larry; Dwyer, Johanna; Picciano, Mary Frances; Fisher, Kenneth; Saldanha, Leila; Yetley, Elizabeth
- Abstract
Nutrient Data Laboratory, USDA, is collaborating with Office of Dietary Supplements to create an analytically verified Dietary Supplement Ingredient Database (DSID). As part of the DSID, variability within and between lots was assessed in MVM products. Using National Health and Nutrition Examination Survey 01-02 supplement use data, the three most common %Daily Value (DV) levels were chosen for 4 nutrients: iron (Fe), vitamin C (VC), folic acid (FA), a-tocopherol (VE). Three MVMs at each %DV level (9 products/nutrient) were chosen randomly. Samples of 2 lots per product were sent to an independent laboratory for analysis. Within-lot sample size (Fe n=2, VC and FA n=3, VE n=4) was estimated using preliminary USDA data on within-day variability in order to detect a 10% difference between lots with 95% confidence. Product coefficients of variability (CV) within-lots were estimated from data expressed as mg/serving (Fe, VC, VE) or µg/serving (FA). CVs by product were 1.7-10;2% for Fe, 1.2-16.4% for VC, 6.3-24.1% for FA, and 2.7-25.2% for VE, indicating lower within-lot product variability for some products and nutrients than other products. ANOVA indicated sample lot-to-lot variance within products and nutrients accounted for <1% of total variability. Although lot-to-lot variance was minimal, additional lots and/or nutrients may need to be tested to assess the impact of between and within lot effects.
- Subjects
UNITED States; IRON; VITAMIN C; FOLIC acid; VITAMIN E; GERIATRIC nutrition; DATABASES
- Publication
FASEB Journal, 2007, Vol 21, Issue 5, pA310
- ISSN
0892-6638
- Publication type
Article