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- Title
Mammographic Density Reduction is Associated to the Prognosis in Asian Breast Cancer Patients Receiving Hormone Therapy.
- Authors
Shia, Wei-Chung; Lin, Li-Sheng; Wu, Hwa-Koon; Chen, Chih-Jung; Chen, Dar-Ren
- Abstract
Introduction: Using mammographic density as a significant biomarker for predicting prognosis in adjuvant hormone therapy patients is controversial due to the conflicting results of recent studies. This study aimed to evaluate hormone therapy-induced mammographic density reduction and its association with prognosis in Taiwanese patients. Methods: In this retrospective study, 1941 patients with breast cancer were screened, and 399 patients with estrogen receptor - positive breast cancer who received adjuvant hormone therapy were enrolled. The mammographic density was measured using a fully automatic estimation procedure based on full-field digital mammography. The prognosis included relapse and metastasis during treatment follow-up. The Kaplan-Meier method and Cox proportional hazards model were used for disease-free survival analysis. Results: A mammographic density reduction rate >20.8%, measured preoperatively and after receiving hormone therapy from 12-18 months, was a significant threshold for predicting prognosis in patients with breast cancer. The disease-free survival rate was significantly higher in patients whose mammographic density reduction rate was >20.8% (P =.048). Conclusion: This study's findings could help estimate the prognosis for patients with breast cancer and may improve the quality of adjuvant hormone therapy after enlarging the study cohort in the future.
- Publication
Cancer Control: Journal of the Moffitt Cancer Center, 2023, p1
- ISSN
1073-2748
- Publication type
Article
- DOI
10.1177/10732748231160991