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- Title
One-year follow-up of chest CT findings in patients after SARS-CoV-2 infection.
- Authors
Chen, Yanfei; Ding, Cheng; Yu, Ling; Guo, Wanru; Feng, Xuewen; Yu, Liang; Su, Junwei; Xu, Ting; Ren, Cheng; Shi, Ding; Wu, Wenrui; Yi, Ping; Liu, Jun; Tao, Jingjing; Lang, Guanjing; Li, Yongtao; Xu, Min; Sheng, Jifang; Li, Lanjuan; Xu, Kaijin
- Abstract
<bold>Background: </bold>Knowledge about the 1-year outcome of COVID-19 is limited. The aim of this study was to follow-up and evaluate lung abnormalities on serial computed tomography (CT) scans in patients with COVID-19 after hospital discharge.<bold>Methods: </bold>A prospective cohort study of patients with COVID-19 from the First Affiliated Hospital, Zhejiang University School of Medicine was conducted, with assessments of chest CT during hospitalization and at 2 weeks, 1 month, 3 months, 6 months, and 1 year after hospital discharge. Risk factors of residual CT opacities and the influence of residual CT abnormalities on pulmonary functions at 1 year were also evaluated.<bold>Results: </bold>A total of 41 patients were followed in this study. Gradual recovery after hospital discharge was confirmed by the serial CT scores. Around 47% of the patients showed residual aberration on pulmonary CT with a median CT score of 0 (interquartile range (IQR) of 0-2) at 1 year after discharge, with ground-glass opacity (GGO) with reticular pattern as the major radiologic pattern. Patients with residual radiological abnormalities were older (p = 0.01), with higher rate in current smokers (p = 0.04), higher rate in hypertensives (p = 0.05), lower SaO2 (p = 0.004), and higher prevalence of secondary bacterial infections during acute phase (p = 0.02). Multiple logistic regression analyses indicated that age was a risk factor associated with residual radiological abnormalities (OR 1.08, 95% CI 1.01-1.15, p = 0.02). Pulmonary functions of total lung capacity (p = 0.008) and residual volume (p < 0.001) were reduced in patients with residual CT abnormalities and were negatively correlated with CT scores.<bold>Conclusion: </bold>During 1-year follow-up after discharge, COVID-19 survivors showed continuous improvement on chest CT. However, residual lesions could still be observed and correlated with lung volume parameters. The risk of developing residual CT opacities increases with age.
- Subjects
COMPUTED tomography; SARS-CoV-2; COVID-19; MULTIPLE regression analysis; HOSPITAL admission &; discharge
- Publication
BMC Medicine, 2021, Vol 19, Issue 1, p1
- ISSN
1741-7015
- Publication type
journal article
- DOI
10.1186/s12916-021-02056-8