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- Title
Anti-D Alloimmunization after RhD-Positive Platelet Transfusion in RhD-Negative Women under 55 Years Diagnosed with Acute Leukemia: Results of a Retrospective Study.
- Authors
Villalba, Ana; Santiago, Marta; Freiria, Carmen; Montesinos, Pau; Gomez, Ines; Fuentes, Carolina; Rodriguez-Veiga, Rebeca; Fernandez, José María; Sanz, Guillermo; Sanz, Miguel Angel; Carpio, Nelly; Solves, Pilar
- Abstract
<bold>Background: </bold>Anti-D alloimmunization can occur when platelets from RhD-positive donors are transfused to RhD-negative patients, due to red blood cell residues in the platelet concentrates. <bold>Methods: </bold>Our objective was to analyze the anti-D alloimmunization rate in a selected group of women under 55 years of age diagnosed with acute leukemia over an 18-year period. We focused the analysis on RhD-negative patients who received RhD-positive platelet transfusions. <bold>Results: </bold>From January 1998 to October 2016, 382 women under 55 years were diagnosed with acute leukemia. A total of 56 patients were RhD-negative, and 48 (85.7%) received RhD-positive platelets. The median number of platelet concentrates transfused per patient was 23, and 48% of all platelet transfusions were RhD-positive. The 48 RhD-negative patients received a total of 949 RhD-positive platelet concentrates. Two patients developed anti-D: a 36-year-old woman with M3 acute myeloblastic leukemia and a 52-year-old patient with a secondary acute myeloblastic leukemia. <bold>Conclusion: </bold>We conclude that there is a need for agreement in the transfusion guidelines on the recommendation of anti-D alloimmunization prophylaxis. We suggest a possible benefit in favor of anti-D prophylaxis in childbearing women with acute leukemia.
- Subjects
BLOOD platelet transfusion; ACUTE leukemia; BLOOD donors; ACUTE myeloid leukemia; PREVENTIVE medicine
- Publication
Transfusion Medicine & Hemotherapy, 2018, Vol 45, Issue 3, p162
- ISSN
1660-3796
- Publication type
Article
- DOI
10.1159/000488804