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- Title
Regulation of Foxo-1 and the angiopoietin-2/Tie2 system by shear stress
- Authors
Chlench, Sven; Mecha Disassa, Nigussie; Hohberg, Margret; Hoffmann, Christian; Pohlkamp, Theresa; Beyer, Gabriele; Bongrazio, Mauro; Da Silva-Azevedo, Luis; Baum, Oliver; Pries, Axel Radlach; Zakrzewicz, Andreas
- Abstract
Abstract: Transcription factor Foxo-1 can be inactivated via Akt-mediated phosphorylation. Since shear stress activates Akt, we determined whether Foxo-1 and the Foxo-1-dependent, angiogenesis-related Ang-2/Tie2-system are influenced by shear stress in endothelial cells. Expression of Foxo-1 and its target genes p27Kip1 and Ang-2 was decreased under shear stress (6dyn/cm2, 24h), nuclear exclusion of Foxo-1 by phosphorylation increased. eNOS and Tie2 were upregulated. No effects on Ang-1 expression were detected. In conclusion, Foxo-1 and Ang-2/Tie2 are part of the molecular response to shear stress, which may regulate angiogenesis.
- Subjects
TRANSCRIPTION factors; PHOSPHORYLATION; NEOVASCULARIZATION; PHYSIOLOGICAL stress
- Publication
FEBS Letters, 2007, Vol 581, Issue 4, p673
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2007.01.028