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- Title
Unravelling the activation mechanisms of protein kinase B/Akt
- Authors
Scheid, Michael P.; Woodgett, James R.
- Abstract
Over the past decade, protein kinase B (PKB, also termed Akt) has emerged as an important signaling mediator between extracellular cues and modulation of gene expression, metabolism, and cell survival. The enzyme is tightly controlled and consequences of its deregulation include loss of growth control and oncogenesis. Recent work has better characterized the mechanism of PKB activation, including upstream regulators and secondary binding partners. This minireview refreshes some old concepts with new twists and highlights current outstanding questions.
- Subjects
PROTEIN kinases; ENZYMES
- Publication
FEBS Letters, 2003, Vol 546, Issue 1, p108
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/S0014-5793(03)00562-3