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- Title
Tumour necrosis factor-α promoter region polymorphisms affect the course of spontaneous HBsAg clearance.
- Authors
Pei-Chi Kao; Jia-Feng Wu; Yen-Hsuan Ni; Ying-Ting Lin; Huey-Ling Chen; Sandy Huey-Jen Hsu; Hong-Yuan Hsu; Mei-Hwei Chang
- Abstract
Background: This study aimed to investigate the roles of tumour necrosis factor-α (TNF-α) gene polymorphisms in the spontaneous clearance of HBsAg after a hepatitis B virus (HBV) infection. Methods: Polymorphisms in the TNF-α (−1031 T to C, −863 C to A, −857 C to T, −308 G to A and −238 G to A transition) gene were evaluated in 274 chronic HBV-infected patients and 194 patients with resolved HBV infection. The peripheral blood mononuclear cells (PBMC) isolated from 77 (28%) of the 274 chronic HBV-infected patients with negative HBeAg and positive antibody to HBeAg were stimulated with HBcAg. Data on TNF-α genotypes and phenotypes in subjects with/without the A allele at the TNF-α−863 promoter single nucleotide polymorphism (rs1800630) were compared. Results: The A allele in the −863 promoter region of the TNF-α gene was present in 154 (56.2%) chronic HBV-infected patients and 87 (44.8%) patients who recovered from HBV infection (odds ratio 1.58; P<0.01). The TNF-α−863 A allele genotype predicted lower TNF-α production by PBMC after in vitro HBcAg stimulation ( P<0.02). Conclusions: The A allele at the −863 locus of the promoter region of the TNF-α gene predicts lower HBcAg-inducible TNF-α secretion. It is also associated with chronicity of HBV infection.
- Subjects
TUMOR necrosis factors; GENETIC polymorphisms; HEPATITIS B virus; LIVER diseases; MEDICAL microbiology
- Publication
Liver International, 2010, Vol 30, Issue 10, p1448
- ISSN
1478-3223
- Publication type
Article
- DOI
10.1111/j.1478-3231.2010.02340.x